Paired Box 5 (PAX5) (C-Term) Peptide
PAX5
Reactivité: Humain
Hôte: Synthetic
BP, WB
N° du produit ABIN5671760
Aperçu rapide pour Paired Box 5 (PAX5) (C-Term) Peptide (ABIN5671760)
Antigène
PAX5
(Paired Box 5 (PAX5))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Séquence
- PPHVPPAGQG SYSAPTLTGM VPGSEFSGSP YSHPQYSSYN DSWRFPNPGL
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti- PAX5 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Indications d'application
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- PAX5 (Paired Box 5 (PAX5))
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Sujet
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This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9,14)(p13,q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternative splicing results in multiple transcript variants encoding different isoforms.
Alias Symbols: ALL3, BSAP
Protein Size: 357 -
ID gène
- 5079
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NCBI Accession
- NM_001280547, NP_001267476
Antigène
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